Alexander Disease

About- Alexander disease also known as fibrinoid leukodystrophy is a rare nervous system disorder due to destroyed myelin, characterized by the disrupted transmission of nerve impulses and impaired nervous system functions.

 Learning disability
 Enlarged head size
 Hydrocephalus (fluid in the brain)
 Enlarged brain
 Development delay
 Failure to thrive
 Impaired mobility
 Speech problems
 Muscle stiffness and restriction of movement (spasticity)
 Lack of coordination (ataxia)
 Nausea and Vomiting
 Mental regression
 Difficulty swallowing, coughing, and breathing
 Sleep disorder
Alexander disease occurs due to a defect in the Glial Fibrillary Acidic Protein (GFAP) gene
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