Dark, thickened, velvety skin in body folds 
Acanthosis nigricans skin patches occur when epidermal skin cells begin to reproduce rapidly. This abnormal skin cell growth is most commonly triggered by Too much Insulin Certain medications include birth control pills, human growth hormones, thyroid medications, high doses of niacin, etc. Stomach cancer, or gastric adenocarcinoma Adrenal gland disorders, such as Addison’s disease Pituitary gland disorders Insufficient thyroid hormones 
Dermatologist Endocrinologist
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