About- Scleroderma is a group of rare diseases that involve the hardening and tightening of the skin and connective tissues may result in changes to the skin, blood vessels, muscles, and internal organs.

Scleroderma is also called systemic sclerosis, progressive systemic sclerosis, or CREST syndrome. “CREST” stands for:
 Raynaud’s phenomenon
 Esophageal dysmotility
 Hardening and tightening of patches of skin shaped like ovals or straight lines, and cover wide areas of the trunk and limbs
 Shiny Skin
 Raynaud's Syndrome
 Acid reflux
 Problems absorbing nutrients due to lack of movement of the intestinal muscles
 Heart, lungs or kidney problem
 Limited movement
 Hair loss
 Calcium deposits, or white lumps under the skin
 Small, dilated blood vessels under the skin’s surface
 Joint pain
 Shortness of breath
 A dry cough
 Difficulty swallowing
 Abdominal bloating after meals

Scleroderma occurs due to overproduction and accumulation of collagen in body tissues. Scientists are not certain about the reason for overproduction of collagen, the body's immune system appears to play a role.
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