Mixed Connective Tissue Disease (Sharp's Syndrome)

About- Mixed connective tissue disease also known as sharp's syndrome, is an autoimmune disease characterized by the existence of high blood levels of a specific autoantibody (anti-U1 ribonucleoprotein, RNP). It’s sometimes called an overlap disease because many of its symptoms overlap with those of other connective tissue disorders, such as lupus, polymyositis, and scleroderma.  
 
Symptoms-
  • Acid reflux
  • Chest pain
  • Fatigue
  • Fever
  • Hardening or tightening patches of skin
  • Malaise
  • Muscle and joint pain
  • Muscle weakness
  • Pain in multiple joints
  • Raynaud's disease
  • Shortness of breath
  • Skin rash
  • Stomach inflammation
  • Swollen fingers or hands
  • Swollen joints
 
Causes-
The exact cause of mixed connective tissue disease is not properly understood. 
 
Specialists to visit-
Dermatologist
Immunologist
Rheumatologist 

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References
https://en.wikipedia.org
https://www.mayoclinic.org
https://www.healthline.com
https://emedicine.medscape.com
https://www.msdmanuals.com

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